Potato has a variety of reproductive uniquenesses besides its clonal propagation by tubers. These traits are controlled by a different kind of genetic control. The reproductive information has been applied to enable inter-specific hybridization to enhance valuable traits, such as disease and pest resistances, from the tuber-bearing Solanum gene pool. Moreover, in the changing climatic scenario, the window for seed production is likely to shrink and the pressure of pathogens might increase in the near future, which will limit the production of quality planting material. Alternatively, true potato seed (TPS) is a promising technology which has shown potential to produce both disease-free planting materials in true seeds form.